Los inicios de la fagoterapia en Chile: los doctores Mercedes Perez Matus y Hugo Vaccaro Kosovich

Mercedes Pérez Matus y Hugo Vaccaro Kosovich fueron destacados médicos y microbiólogos de la cátedra ordinaria de Bacteriología de la Facultad de Medicina de la Universidad de Chile. En 1931, ambos médicos fueron contratados por la Facultad de Medicina para reorganizar la convulsionada Cátedra de Bacteriología luego de la crisis política de 1931. En el mismo período el destacado investigador del instituto Pasteur Eugéne Wollman vino a Chile a dirigir el Instituto Sanitas (1929-1931), incorporando en nuestro país el conocimiento sobre los bacteriófagos y las técnicas para su aislamiento. La prolongada labor docente y de investigación de Vaccaro y Pérez se extendió por casi 40 años (1931-1970). Publicaron numerosos artículos científicos, siendo uno de sus temas preferidos, en los primeros años, el estudio de los bacteriófagos que aprendieron junto a Wollman. En la década de los 40, bajo el liderazgo de los Dres. Vaccaro y Pérez, se inició la fagoterapia en Chile.

Mercedes Perez Matus and Hugo Vaccaro Kosovich were distinguished doctors and microbiologists from the ordinary chair of Bacteriology at the Faculty of Medicine of the University of Chile. In 1931, both doctors were hired by the F aculty of Medicine to reorganize the convulsed Chair of Bacteriology after the political crisis of 1931. In the same period, the prominent Pasteur Institute researcher Eugene Wollman came to Chile to direct the Sanitas Institute (1929-1931), incorporating in our country the knowledge about bacteriophages and the techniques for their isolation. The long teaching and research work of Vaccaro and Pérez spanned almost 40 years (1931-1970). They published numerous scientific articles, being one of their favorite topics, in the early years, the study of bacteriophages that they learned together with Wollman. In the 1940s, under the leadership of Drs. Vaccaro and Pérez, phage therapy began in Chile.

[Semina morbi or seeds of disease]. / Semina morbi o semillas de enfermedad.

Already in ancient times there was the idea that tiny animals or insects could cause diseases when ingested or breathed. In parallel, several philosophers developed the concept of seeds to explain the composition of the world. Both concepts were amalgamated in the brilliant idea of seeds of disease that was spread in the famous poem "De rerum natura" by the Epicurean philosopher Lucretius. The idea was refined in the Renaissance by the prominent physician Girolamo Fracastorius with his famous semina morbi (seeds of disease) that explained contagion. The germinal theory of microbes of the s. XIX did nothing more than assign to this already millenary idea a material substratum.

Semina morbi o semillas de enfermedad / Semina morbi or seeds of disease

Resumen Ya en la antigüedad existía la idea de que pequeñísimos animales o insectos podían causar enfermedades al ser ingeridos o respirados. En forma paralela, varios filósofos desarrollaron el concepto de semillas para explicar la composición del mundo. Ambos conceptos fueron amalgamados en la genial idea de semillas de enfermedad que fue difundida en el célebre poema del filósofo epicúreo Lucrecio denominado "De rerum natura" o "Sobre la naturaleza de las cosas". La idea fue refinada en el Renacimiento por el destacado médico renacentista Gerónimo Fracastorius con sus famosas semina morbi (semillas de enfermedad) que explicaban el contagio. La teoría germinal de los microbios del s. XIX no hizo más que adjudicarle a esta idea ya milenaria un substrato material.

Abstract Already in ancient times there was the idea that tiny animals or insects could cause diseases when ingested or breathed. In parallel, several philosophers developed the concept of seeds to explain the composition of the world. Both concepts were amalgamated in the brilliant idea of seeds of disease that was spread in the famous poem "De rerum natura" by the Epicurean philosopher Lucretius. The idea was refined in the Renaissance by the prominent physician Girolamo Fracastorius with his famous semina morbi (seeds of disease) that explained contagion. The germinal theory of microbes of the s. XIX did nothing more than assign to this already millenary idea a material substratum.

El origen mítico de la sífilis

Resumen En 1530 el célebre médico renacentista veronés Gerónimo Fracastoro escribió su inmortal poema "Syphilis sive morbus gallicus libri tres" (La sífilis o el mal francés en tres libros). Esta obra es un hermoso poema en latín de 1300 versos hexámetros. En el primer libro se describen las causas de la enfermedad y el cuadro clínico característico. En el segundo libro se mencionan los principales tratamientos, destacando especialmente el mercurio. Finalmente, en el tercer libro se relata como los marinos españoles encontraron nativos de la isla de Santo Domingo en América infectados con sífilis y cómo estos explicaban el origen de esta devastadora enfermedad. Los nativos relataban como su ancestro pastor llamado Sífilus, había desafiado en tiempos inmemoriales al dios Apolo o Febo, desatando así su ira y siendo por ello el primer infectado. Del mito del pastor Sífilus deriva la actual denominación de la enfermedad que en tiempos de Fracastoro fue llamada el "mal francés", "morbo gálico" o "lúes venérea".

Abstract In 1530 the famous Veronese Renaissance doctor Geronimus Fracastorius wrote the immortal poem "Syphilis sive de morbo gallicus libre tres" (The three books of syphilis or French disease). This work is a beautiful Latin poem of 1300 hexameter lines. The first book describes the causes of the disease and the characteristic clinical presentation. In book two the main treatments are mentioned, especially mercury. Finally, in the third book, it is related how the Spanish sailors found natives of the island of Santo Domingo in America infected with syphilis and how they explained the origin of this devastating disease. The natives recounted how their shepherd ancestor named Syphilus had challenged the god Apollo or Phoebus in time immemorial, thus unleashing his wrath and thus being the first infected. From the myth of the shepherd Syphilus derives the current denomination of the disease that in times of Fracastoro was called the "French disease", "Gallic disease" or "venereal lues".

Los microbios de Linneo / Linnaeus' microbes

Resumen Uno de los grandes genios de la biología fue el médico sueco Carlos Linneo (1707-1778). Se lo denominó princeps botanicorum por su gran aporte a la clasificación de las plantas. Sin embargo, su fama imperecedera se debe a su obra Systema Naturae en que crea un sistema taxonómico binomial para clasificar a todos los seres vivos y no vivos en tres reinos: el reino mineral, el reino vegetal y el reino animal. En su esquema taxonómico, los animalículos o microorganismos descubiertos por el sabio neerlandés Antoine van Leeuwenhoek en 1676, fueron clasificados tentativamente en el reino animal, dentro de la clase Vermes o Gusanos. La idea de que estos animalitos fueran la causa de las enfermedades infecciosas fue planteada por Linneo y desarrollada en profundidad por Johannes C. Nyander y Johannes Carolus Roos, dos de sus discípulos, quienes publicaron esta idea en sus tesis Exanthemata viva en 1757 y Mundus invisibilis en 1767, respectivamente.

Abstract One of the great geniuses of biology was the Swedish physician Carlos Linnaeus (1707-1778). He was called princeps botanicorum for his great contribution to the classification of plants. However, his undying fame is due to his work Systema Naturae in which he creates a binomial taxonomic system to classify all living and non-living beings into three kingdoms: the mineral kingdom, the plant kingdom and the animal kingdom. In his taxonomic scheme, the animalicles or microorganisms discovered by the Dutch scholar Antoine van Leeuwenhoek in 1676, were tentatively classified in the animal kingdom, within the class Vermes or Worms. The idea that these little animals were the cause of infectious diseases was imagined by Linnaeus and developed in depth by Johannes C. Nyander and Johannes Carolus Roos, two of his disciples, who published this idea in their theses Exanthemata viva in 1757 and Mundus invisibilis in 1767, respectively.

Los microbios de Linneo.

One of the great geniuses of biology was the Swedish physician Carlos Linnaeus (1707-1778). He was called princeps botanicorum for his great contribution to the classification of plants. However, his undying fame is due to his work Systema Naturae in which he creates a binomial taxonomic system to classify all living and non-living beings into three kingdoms: the mineral kingdom, the plant kingdom and the animal kingdom. In his taxonomic scheme, the animalicles or microorganisms discovered by the Dutch scholar Antoine van Leeuwenhoek in 1676, were tentatively classified in the animal kingdom, within the class Vermes or Worms. The idea that these little animals were the cause of infectious diseases was imagined by Linnaeus and developed in depth by Johannes C. Nyander and Johannes Carolus Roos, two of his disciples, who published this idea in their theses Exanthemata viva in 1757 and Mundus invisibilis in 1767, respectively.

Leeuwenhoek y sus animálculos / Leeuwenhoek and his little animals

Resumen Antoine van Leeuwenhoek (1632-1723) fue un comerciante de telas holandés y microscopista autodidacta, a quien se le considera el padre de la Microbiología. Sus sorprendentes lentes y agudas observaciones microscópicas durante casi cinco décadas posibilitaron por primera vez desentrañar los secretos del microcosmos. Este trabajo de investigación tiene como objetivo principal que el lector pueda acceder de manera directa a algunas de sus famosas cartas dirigidas a la Sociedad Real de Londres, anunciando el descubrimiento de sus celebérrimos animálculos.

Abstract Antoine van Leeuwenhoek (1632-1723) was a Dutch cloth merchant and self-taught microscopist who is considered the father of Microbiology. His marvellous lenses and keen microscopic observations over nearly five decades made it possible for the first time to unravel the secrets of the microcosm. The main objective of this work is that the reader can directly access some of his famous letters addressed to the Royal Society of London, announcing the discovery of his famous little animals.

[Leeuwenhoek and his little animals]. / Leeuwenhoek y sus animálculos.

Antoine van Leeuwenhoek (1632-1723) was a Dutch cloth merchant and self-taught microscopist who is considered the father of Microbiology. His marvellous lenses and keen microscopic observations over nearly five decades made it possible for the first time to unravel the secrets of the microcosm. The main objective of this work is that the reader can directly access some of his famous letters addressed to the Royal Society of London, announcing the discovery of his famous little animals.

[The first chilean female doctors: Eloísa Díaz Insunza and Ernestina Pérez Barahona]. / Las primeras médicas de Chile y Latinoamérica: Eloísa Díaz Insunza y Ernestina Pérez Barahona.

Dr. Eloísa Díaz Insunza (1866-1950) was the first woman to become a doctor-surgeon in Chile and Latin America in 1887. Less known is her distinguished colleague, Dr. Ernestina Pérez Barahona (1865-1951), the second woman graduated in Chile as a physician, only seven days after Dr. Diaz. Dr. Diaz entered the School of Medicine of the University of Chile in 1881 and Dr. Pérez in 1883. However, both graduated from Bachelor of Medicine and Pharmacy in 1885 and received their degree in 1887. This paper highlights the extraordinary parallelism in their medical studies.

Las primeras médicas de Chile y Latinoamérica: Eloísa Díaz Insunza y Ernestina Pérez Barahona / The first chilean female doctors: Eloísa Díaz Insunza and Ernestina Pérez Barahona

Dr. Eloísa Díaz Insunza (1866-1950) was the first woman to become a doctor-surgeon in Chile and Latin America in 1887. Less known is her distinguished colleague, Dr. Ernestina Pérez Barahona (1865-1951), the second woman graduated in Chile as a physician, only seven days after Dr. Diaz. Dr. Diaz entered the School of Medicine of the University of Chile in 1881 and Dr. Pérez in 1883. However, both graduated from Bachelor of Medicine and Pharmacy in 1885 and received their degree in 1887. This paper highlights the extraordinary parallelism in their medical studies.